Osteoprotegerin in bone metastases: mathematical solution to the puzzle.
Bone is a common site for cancer metastasis.To create space for their growth, cancer cells stimulate bone resorbing osteoclasts.Cytokine RANKL is a key Water Repellent Jacket osteoclast activator, while osteoprotegerin (OPG) is a RANKL decoy receptor and an inhibitor of osteoclastogenesis.Consistently, systemic application of OPG decreases metastat